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TISSUE STIMULATORS

Bio-stimulators are a breakthrough in aesthetic medicine and an excellent solution for those who have tired, dry skin with aging signs, such as sunken cheeks, wrinkles or loss of defined facial oval. Bio-stimulators include preparations based on peptides, calcium hydroxyapatite, collagen, amino acids or L-polylactic acid and, of course, hyaluronic acid.
Each of them has a slightly different composition and produces different effects. However, they all have one thing in common: they are state-of-the-art solutions and have high effectiveness. Thanks to them, you can lift tissues without the produced by fillers or moisturise the skin better than mesotherapy.
Stimulators encourage the skin to self-renew by stimulating fibroblasts and production of collagen and elastin.
Bio-stimulators are also a great alternative to classic mesotherapy for people who are afraid of needles – some preparations require only 4-5 insertions to nourish the whole face!
During the consultation, a physician will help you choose the most suitable type of Bio-stimulators .

TYPES OF BIO-STIMULATORS

1

PROFHILO®

Thanks to the use of natural, selected hyaluronic acid of the highest concentration (up to 64 mg in one dose) and a new generation of hyaluronic acid crosslinking, Profhilo® rejuvenates not only the skin, but also the subcutaneous tissue, which is the skin’s scaffolding.
Hyaluronic acid is released from the injection site for a long time, remodelling and restoring the skin components lost over the years. In addition, hyaluronic acid chains with a selected length stimulate the cells of the dermis to synthesise collagen and elastin, so it regains its firmness and elasticity.
Profhilo® procedures strengthen and thicken the skin, smooths out wrinkles in the cheek area, sub-cheek area as well as in the area of “crow’s feet”. It also slims facial features restoring proper skin tension, and at the same time the applied Profhilo® youth molecule impacts the skin like millions of springs, restoring facial contour and giving the effect of firmness, which has been lost over the years.
The procedure is performed with a special 5-point technique.
Optimal results are achieved after performing a series of 2 procedures at 30-day intervals.

2

NUCLEOFILL®

Nucleofill® is a modern preparation for deep skin rejuvenation and bioresurfacing. This innovative treatment works on three levels: lifting, anti-oxidation and hydration.
This scientifically proven method of skin biostimulation contains polynucleotides, which, in a three-way mechanism, stimulate the skin to rebuild itself.
The first direction of activity involves receptors on fibroblasts in the skin. Thanks to this stimulation, they are transformed into myofibroblasts. Production of type I collagen and elastin is stimulated, resulting in skin thickening and lifting. The second mechanism is “scavenging” free radicals and antioxidant activity. In addition, polynucleotides bind water and provide long-term isotonic hydration of the extracellular matrix. As a result, the skin becomes moisturised and firm.
Nucleofill® is perfect for those who notice loss of elasticity and signs of aging, and whose skin is lackluster and needs deep hydration. The treatment can be performed regardless of the age or skin type. The procedure is performed using a 5-point technique.
Optimal results are achieved after performing a series of 2 procedures at 30-day intervals.

3

SCULPTRA®

Sculptra ® is a suspension of microparticles of L-polylactic acid in sterile water for injection. The product is injected subcutaneously or deep intradermally. It is believed that slow disintegration of the particles in the body stimulates production of connective fibrous tissue, and thus the synthesis of collagen. In a short time Sculptra® increases the volume of collapsed skin areas. After 2-3 treatments performed at 4-6 weekly intervals, we can observe gradual, but noticeable improvement in skin condition, which gains a natural youthful appearance. Unlike in case of other procedures, the achieved effect lasts up to 2 years.

During this time, L-polylactic acid continues to impact cells called fibroblasts, which are responsible for production of collagen proteins in the skin. When it happens, collagen levels increase and the skin becomes softer, tighter and visibly rejuvenated and firmer, and its thickness increases.

During this procedure, a physician improves a contour of Patients’ face, fills the area around the zygomatic bone, restores the shape of the cheeks and the regular jaw line, lifts the fallen chin and smooths the nasolabial folds. Another advantage of using Sculptra® is that this preparation restores volume in the face. Sculptra ® can be used to increase the volume of sunken skin, especially for the correction of skin depressions such as furrows, wrinkles, folds of skin, scars and signs of aging. SCULPTRA® can also be used to correct symptoms of large atrophy of fat (lipoatrophy) in the face.

After the procedure, a physician gives massage. For the next 14 days, the Patient should also perform it.

4

SUNEKOS® 1200

Sunekos® 1200 is an injectable preparation with antioxidant properties for severe wrinkles and damaged skin.
It restores youthful, natural features by improving facial volume loss, reducing wrinkles and hydrating the skin. The patent-protected formula contains hyaluronic acid and a combination of amino acids, collagen and elastin precursors – glycine, L-valine, L-alanine, L-leucine, L-lysine and L-proline. This combination helps stimulate regeneration of the extracellular matrix, leading to skin biogenesis. This results in formation of new skin protein fibres, such as type I collagen, type III collagen and the most difficult to reconstruct type IV collagen and elastin. This process is called skin biogenesis. It is possible only by selecting the right amino acids in terms of quality and quantity and combining them with hyaluronic acid salt.
Uniqueness of the preparation lies also in a wide spectrum of tissue stimulation that can be observed after the procedure. These include moisturising deep and superficial skin layers, a very natural volumetric effect and smoothing out facial wrinkles.
The first effects can be observed as early as 10 days after the procedure, and a very subtle and natural volumetric effect is visible immediately.
During the procedure a physician combines two vials with amino acids and hyaluronic acid.
Optimal effects are achieved after performing a series of 3 procedures at intervals of three months and with the addition of Sunekos ®200 mesotherapy.

5

LINERASE

LINERASE atelocollagen constitutes a new category of stimulator for tissue reconstruction and restoration. By creating optimal physiological conditions for production of new collagen, LINERASE procedures effectively regenerate and repair skin defects, treat scars and stretch marks, reduce fine wrinkles or skin flabbiness and improve its elasticity, resilience and density. Thanks to a high safety profile and gentleness, LINERASE can be used in any, even the most delicate area of the face as sell as the whole body. It is especially recommended in the area of eyes, lips, cleavage, neck, abdomen, and hands.
After preparing the solution from powder, LINERASE has a liquid form. It is administered intradermally in the form of mesotherapy. It is applied with a thin and very short needle. A physician administers small deposits of the product at intervals of 1-3 cm over the entire treatment site. After the procedure, a gentle massage is performed at the injection site.
The first effects in the form of skin tension, brightening and irritation alleviation may appear already after 7 days and they increase throughout the therapy. The full effect of the treatment (tension, concentration, thickening of flabby skin, fine wrinkle fillers and skin defects) is obtained within 4 weeks from the end of the therapy (3-4 procedures). It lasts for about 12-18 months. After this time, the effect may be prolonged through reminder treatment consisting of 1 procedure per quarter.

6

CRYSTALYS

Crystalys belongs to a group of strong stimulators of collagen synthesis. The active component contained in the preparation, calcium hydroxyapatite, naturally occurs in the human body and is fully biodegradable after 2 years. During this period, its impact is long-lasting and occurs in two stages: It improves the volume of the skin and models the shape of the face. Its double action consists in reconstruction of skin structure and stimulation of collagen production, which is responsible for skin elasticity and firmness. As a result, it not only fills and smooths wrinkles, but also supports biorevitalisation of the skin, which gives a long-lasting and natural effect.
Crystalys consists of calcium hydroxyapatite microspheres with a diameter of 25-45 microns, which are suspended in a gel carrier. It is fully biocompatible and over time it is safely and naturally absorbed by the body. Its components – calcium and phosphorus – are natural components of human tissue, which means that Crystalys does not cause allergic reactions.
The stimulating effect is greater than after administration of hyaluronic acid, while the volumetric effect is smaller – thus Crystalys works very well in Patients with a round face, a large amount of body fat, saggy cheeks (“liquid facelift”), signs of aging associated with sagging facial skin and body. Due to its strong but discreet action, it is an excellent product for male skin rejuvenation.

7

EJAL 40®

Ejal 40® contains an active ingredient in the form of hyaluronic acid, which is designed differently – specifically for the innovative 4 BPR points treatment technique. A physician makes a shallow subcutaneous injection with only 4 small deposits in special points (BioRevitalization Points) on each side of the face. The product contains the latest generation of hyaluronic acid with an average molecular weight (MMW) of 1200-1800 kDa and a concentration as high as 40 mg/2ml. Due to precise selection of solely medium hyaluronic acid chains and the structure of a left-handed helix in the electrochemical process, so-called hydrogen bridges stabilising the structure are formed (interchain ion bonding). As a result, chains that make up EJAL 40® break down gradually over a long period of time, releasing short fragments into the skin. These, in turn, by activating receptors located on the surface of fibroblasts, stimulate production of native extracellular matrix (Extra Cellular Matrix ECM), i.e. hyaluronic acid, collagen and elastin, among others, thus strongly rejuvenating the skin. EJAL 40® does not contain any chemical additives.
Optimal results are achieved after a series of 3 procedures at 30-day intervals.

8

JALUPRO®

JALUPRO®, also known as amino acid replacement therapy, is based on high concentrations of hyaluronic acid, glycine, L-proline, L-lysine and L-leucine, thanks to which cells receive necessary substances necessary for proper functioning and development. It can also be successfully used for acceleration of healing after other, more invasive aesthetic medicine procedures.
There are two types of JALUPRO® products: classic one and HMW.
JALUPRO® classic restores skin radiance and elasticity and prevents loss of firmness. It excellently impacts the face and body. Reduces wrinkles and prevents formation of elastosis. Improves the appearance of scars – including acne scars, keloids and stretch marks.
JALUPRO® HMW is designed to bioregenerate specific areas of the skin that are most prone to the formation of deep wrinkles and folds, such as the skin of the neck and cleavage.
Optimal results are achieved after a series of 3-4 procedures at 10-day intervals or, in case of JALUPRO® HMW, after a series of 3 procedures at 20-day intervals.

9

TWAC EYES®

The most powerful and safe under-eye stimulator, which helps to remove a tired look.
TwAc Eyes® is a biostimulator created specifically for use in the eye area. This makes it completely safe. It fully removes dark circles under the eyes, moisturizes and fights fine lines. In addition, it smooths and lifts the skin under the eyes.
TwAc Eyes® is a unique system consisting of three components. The basic one is deoxyribonucleic acid in high concentration of 250-350 kDa.
Rich composition stimulates the process of skin reconstruction, accelerates the process of re-epithelialisation, increases metabolic activity of cells, stimulates angiogenesis, creates a barrier for free radicals and of course moisturizes.
Optimal results are achieved after performing a series of 3-4 procedures at 7–10-day intervals.

10

LUMI EYES

Lumi Eyes is a modern tissue stimulator used in needle mesotherapy procedures around the eyes and the tear through with a filling effect, but without the side effects of lymphedema. The product rebuilds damage to the dermis with the help of polynucleotides, which have a regenerative effect. They act as bricks complementing tissue defects. Lumi Eyes moisturises and rejuvenates the skin, removing the symptoms of fatigue and bruising. Wrinkles are reduced, tissues are slightly filled and skin becomes radiant.
The product is especially recommended for those who are prone to lymphedema or experienced a Tyndal effect after administration of hyaluronic acid in the eye area.
Optimal results are achieved after a series of 2 procedures at intervals of 20-30 days.

WHAT IS THE AGING PROCESS?

Aging means diminished ability of cells to respond to environmental stress. This results in a natural and irreversible accumulation of intracellular damage that overwhelms the body’s ability to repair itself.
This is a progressive process that begins around the age of 25. The process of turning the first wrinkles to more visible folds, and volume loss to skin sagging, usually takes several decades! Facial skin aging cannot be compared to the aging of the rest of the body because facial skin is subject to facial expressions and the force of gravity. Constant movements of the skin as well as sun exposure, smoking and poor nutrition are responsible for skin aging. Genetic factors also play an important role. We know more and more about the factors that accelerate aging, and we gain more and more knowledge about how to slow down this natural physiological phenomenon and even improve some aspects related to it.
There are two types of skin aging: intrinsic aging, or the consequence of passage of time, which affects every organism and depends on genetic and physiological factors, sometimes also on disease factors, and extrinsic aging, associated with conditions and lifestyle, primarily sun exposure, but also tobacco intoxication, stress or pollution. At the intersection of both processes, there is oxidative stress, one of the main causes of skin aging. It is caused primarily by free radicals, which biologically damage the structures of our cells. The body itself also produces free radicals, but our cells have an appropriate defence system against their negative effects. As we age, a mismatch develops between these irritations and our ability to defend ourselves.
Fortunately, modern aesthetic medicine rushes to help. Using a wide range of less and more invasive procedures, we are able to significantly slow down or even partially reverse the effects of aging.

BEFORE AND AFTER GALLERY

I highly recommend!

JUSTYNA GRADEK

PROCEDURE

During the consultation, we discuss the expected effect and chose the best method for the Patient. Before the treatment an anaesthetic ointment is applied, which significantly reduces pain sensations – the injections feel similar to mosquito bites. During the procedure, a selected preparation is administered in a form adjusted to the technique.

RECOVERY

Redness and bubbles, which usually appear at the site of injections after administration of tissue stimulator, disappear within 1-2 days. In addition, swelling or discomfort may occur. It must be remembered that some stimulators are designed to cause controlled inflammation. You will be informed about the expected healing process by a physician performing the procedure.

HOW SHOULD I PREPARE?

The procedure does not require much preparation.

Do not consume alcohol, caffeine or drugs 24 hours before the procedure.

One week before the procedure, do not take common painkillers, as they thin the blood and may cause more bruising after insertions. Garlic and onion have a similar effect.

If you take NSAIDs, talk to your GP and ask if you can discontinue them two weeks before your procedure. If your GP refuses, don’t discontinue your medication on your own! The procedure can still be performed, but you must expect more bruising.

Two weeks before the procedure, you can start taking vitamin C, which will strengthen capillary walls and thus reduce formation of bruises.

EFFECT

The effects of bio-stimulators appear at different times, depending on the preparation used. The effects are usually not visible right away, but they gradually gain strength and last from about 6 months to 2 years.

Bio-stimulators tighten and moisturise the skin, eliminate fine wrinkles. The oval of the face is elevated, cheekbones become more prominent, dark circles and puffiness under the eyes are reduced. In addition, deep folds become shallower and the whole skin looks radiant. With certain products, visibility of any acne scars or stretch marks are reduced when applied to the body.

As a result, the aging process is effectively slowed down, and the face gains a “fresh” look without the obvious interference of aesthetic medicine.

CONTRAINDICATIONS

There are not many contraindications to tissue stimulator treatment but they must be taken into consideration. Below you will find the most important of them.

Asymptomatic carrier of hepatitis B or hepatitis C.

Viral hepatitis often affects autoimmune reactions. It mainly depends on the stage of the disease as well as its activity. Only your attending physician may decide whether you are eligible for a aesthetic medicine procedure. Ask them for a written consent for the procedure. Only then, we can perform the procedure.

Diabetes.

In case of advanced diabetes wound healing is impaired. However, when treated and controlled, diabetes is not a problem. If you have diabetes, please ask your attending physician for a written consent for the aesthetic medicine procedure and present it to us on the day of the procedure.

Active cancer.

Cancer that occurred less than 5 years prior to the procedure.

Chemo- and radiotherapy

Autoimmune diseases apart from thyroid disease, acquired vitiligo, and alopecia areata. For example, these diseases include psoriasis, rheumatoid arthritis, lupus, myasthenia gravis, multiple sclerosis, amyotrophic lateral sclerosis, sarcoidosis, Crohn’s disease, ulcerative colitis.

Treatment with Izotec or its substitutes less than 6 months prior the procedure date.

Steroids, except asthma medications and inhaled steroids, taken less than one month prior to the scheduled procedure.

Fungal medications or antibiotics taken less than one week prior to the procedure.

Tendency to keloids.

haemophilia.

Epilepsy.

Pregnancy and breastfeeding. We do not perform procedures in pregnant ladies or nursing mothers, even with the physician’s consent. When it comes to children, one can’t be too careful!

Asymptomatic HIV infection or active AIDS.

Skin diseases in the planned treatment site.

Fever, viral or bacterial infection on the day of the procedure.

WHY IS IT WORTH VISITING PRINCESSE?

EXPERIENCE

Our clinic was established in 2005, thanks to which we have gained vast experience. We have performed over 30,000 procedures. We are also one of the leading training facilities for physicians and cosmetologists in Poland.

QUALITY

At Princesse, we use only the highest quality preparations obtained directly from manufacturers. Avoiding wholesalers, we fully reduce the risk of purchasing inauthentic or substandard products.

SAFETY

We have all medical devices that are needed in case of sudden complications and we employ physicians with experience not only in treating aesthetic medicine complications but also in emergency procedures.

ABOUT PRINCESSE

Princesse is a modern aesthetic medicine clinic and training centre. It was established in 2005. Thanks to extensive experience and over 30,000 procedures performed to date, we have been able to select only the best procedures and equipment.
Princesse employs highly specialised medical and cosmetology staff, who continue to improve their skills by participating in seminars and conferences devoted to the fields they practice, both in Poland and worldwide.
At Princesse, we focus on naturalness and perfection as well as spectacular effects presented by models and celebrities. We believe that aesthetic medicine procedures are meant not to be a disguise, but to emphasise and highlight the strengths that each of us has.

THESE ARE THE PRODUCTS THAT WE USE

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